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Abstract #3168

High-Throughput Diffusion-Tensor-Imaging of Mouse Brains using a four-coil system

John C Nouls 1 , Alexandra Badea 1 , Gary P Cofer 1 , and G Allan Johnson 1

1 Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States

Diffusion-tensor imaging of mouse brains, used in conjunction with population atlases and statistical methods, can detect subtle pathologies. The total scan time can be prohibitive. We present a parallel acquisition, four-coil system increasing diffusion-tensor imaging throughput in a small bore, 7T scanner. The geometry of the coil system and its shielding has been optimized to preserve SNR, enabling a decrease in imaging time per specimen of 63%. The fractional anisotropy measurement bias due to off-center imaging was 9%. Bringing each coil slightly closer to the magnet isocenter may further decrease imaging time towards the maximum 75% reduction achievable.

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