Abstract #3189
Proton Observed Phosphorus Editing (POPE) for in vivo detection of phospholipid metabolites
Jannie P. Wijnen 1,2 , Dennis J.W. Klomp 1 , Christine I.H.C Nabuurs 3 , Robin A. de Graaf 4 , Irene M.L. van Kalleveen 1 , Wybe J.M. van der Kemp 1 , Peter R. Luijten 1 , Mark C. Kruit 2 , Andrew Webb 2 , Hermien E. Kan 2 , and Vincent O. Boer 1
1
Radiology, University Medical Centre
Utrecht, Utrecht, Utrecht, Netherlands,
2
Radiology,
Leiden University Medical Centre, Leiden, Zuid Holland,
Netherlands,
3
Radiology,
Maastricht University, Maastricht, Limburg, Netherlands,
4
Radiology,
Yale University, New Haven, CT, United States
We demonstrate the enhanced sensitivity of Proton
Observed Phosphorus Editing (POPE) over direct
31
P
MRS with Ernst angle excitation for
1
H-
31
P
coupled metabolites at 7 Tesla. POPE sequences were
developed for detecting phosphocholine (PC),
phophoethanolamine (PE), glycerophosphocholine (GPC),
and glycerophosphoethanolamine (GPE) on the
1
H
channel, thereby using the enhanced sensitivity of the
1
H
nuclei over
31
P
detection. POPE editing showed an enhanced sensitivity
of 2.8 in an ideal phantom experiment as compared to
direct
31
P
MRS with Ernst angle excitation. In vivo, despite
increased relaxation losses, significant gains in SNR of
30-40% were shown for these metabolites in the human
brain.
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