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Abstract #3189

Proton Observed Phosphorus Editing (POPE) for in vivo detection of phospholipid metabolites

Jannie P. Wijnen 1,2 , Dennis J.W. Klomp 1 , Christine I.H.C Nabuurs 3 , Robin A. de Graaf 4 , Irene M.L. van Kalleveen 1 , Wybe J.M. van der Kemp 1 , Peter R. Luijten 1 , Mark C. Kruit 2 , Andrew Webb 2 , Hermien E. Kan 2 , and Vincent O. Boer 1

1 Radiology, University Medical Centre Utrecht, Utrecht, Utrecht, Netherlands, 2 Radiology, Leiden University Medical Centre, Leiden, Zuid Holland, Netherlands, 3 Radiology, Maastricht University, Maastricht, Limburg, Netherlands, 4 Radiology, Yale University, New Haven, CT, United States

We demonstrate the enhanced sensitivity of Proton Observed Phosphorus Editing (POPE) over direct 31 P MRS with Ernst angle excitation for 1 H- 31 P coupled metabolites at 7 Tesla. POPE sequences were developed for detecting phosphocholine (PC), phophoethanolamine (PE), glycerophosphocholine (GPC), and glycerophosphoethanolamine (GPE) on the 1 H channel, thereby using the enhanced sensitivity of the 1 H nuclei over 31 P detection. POPE editing showed an enhanced sensitivity of 2.8 in an ideal phantom experiment as compared to direct 31 P MRS with Ernst angle excitation. In vivo, despite increased relaxation losses, significant gains in SNR of 30-40% were shown for these metabolites in the human brain.

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