Abstract #3239
Quantitative assessment of hematocrit, hemoglobin concentration and oxygenation effects on the longitudinal relaxation time of blood
Wenbo Li 1,2 , Ksenija Grgac 1,2 , Alan Huang 1,3 , Qin Qin 1,2 , Nirbhay Yadav 1,2 , and Peter Van Zijl 1,2
1
Department of Radiology, Johns Hopkins
University School of Medicine, Balitmore, MD, United
States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
3
Current
Address: Philips Healthcare, Best, Netherlands
Here we present a theory for the water proton T1 of
blood that takes into account the effect of hematocrit,
oxygenation and hemoglobin concentration, and validate
it on extensive T1 data acquired from whole blood and
lysed blood at 3T, 7T, 9.4T, 11.7T and 16.4T. The theory
involves the contributions of different mechanisms
(paramagnetic effect, water tumbling hindrance) to blood
T1 and can be used to predict blood T1 at multiple
fields. As such it can provide reference values for
perfusion-based quantification experiments such as ASL
(Arterial Spin Labeling) and VASO (Vascular Space
Occupancy).
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