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Abstract #3239

Quantitative assessment of hematocrit, hemoglobin concentration and oxygenation effects on the longitudinal relaxation time of blood

Wenbo Li 1,2 , Ksenija Grgac 1,2 , Alan Huang 1,3 , Qin Qin 1,2 , Nirbhay Yadav 1,2 , and Peter Van Zijl 1,2

1 Department of Radiology, Johns Hopkins University School of Medicine, Balitmore, MD, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Current Address: Philips Healthcare, Best, Netherlands

Here we present a theory for the water proton T1 of blood that takes into account the effect of hematocrit, oxygenation and hemoglobin concentration, and validate it on extensive T1 data acquired from whole blood and lysed blood at 3T, 7T, 9.4T, 11.7T and 16.4T. The theory involves the contributions of different mechanisms (paramagnetic effect, water tumbling hindrance) to blood T1 and can be used to predict blood T1 at multiple fields. As such it can provide reference values for perfusion-based quantification experiments such as ASL (Arterial Spin Labeling) and VASO (Vascular Space Occupancy).

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