B1 and B0 Sensitivity of Spin-Lock Preparation Pulses for Whole-Brain Quantitative T1rho Mapping

T1ρ mapping has found application for a variety of brain diseases. However, to accurately quantify T1ρ in the brain, particularly in difficult regions near air-tissue interfaces such as portions the frontal lobe, new spin-lock prep pulses are needed. This work simulates the T1ρ quantification accuracy of a number of spin-lock prep pulses, including those with adiabatic excitation and refocusing pulses, over an expected range of B1 and B0 field inhomogeneities calculated from 24 in vivo whole-brain scans. It is shown that use of adiabatic excitation pulses improves T1ρ accuracy in regions of the brain susceptible to B1 and B0 offsets.

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