Abstract #3270
Comparison of concentration-dependent signal intensities of MRI contrast media solutions obtained at different pulse sequences at 3T and 7T
Thomas Frenzel 1 , Pavol Szomolanyi 2 , Iris Noebauer-Huhmann 2 , Martin Rohrer 1 , Gregor Jost 1 , and Siegfried Trattnig 2
1
Bayer Healthcare, Berlin, Germany,
2
High
Field MR Centre, Department of Biomedical Imaging and
Image-Guided Therapy, Medical University of Vienna /
Vienna General Hospital, Vienna, Austria
The concentration dependent change of the signal
intensity (SI) of commercially available contrast media
(CM) were investigated in-vitro in human plasma at 37C
at 3T and 7T, using spin- and gradient echo sequences. A
nearly linear correlation between Gd-concentration and
SI was observed only for very low concentrations
(<1-3mM). At higher concentrations stable, increasing or
decreasing SIs were observed. The dominant parameters
influencing the SI were the pulse sequence, the field
strength, the protein binding of the CA as well as their
relaxivities, and their in-vivo concentrations. These
results should be considered for (semi-) quantitative
image evaluation.
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