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Abstract #3326

On the feasibility of QSM in MR-invisible regions

Diego Hernando 1 , Debra E. Horng 1,2 , Samir D. Sharma 1 , and Scott B. Reeder 1,2

1 Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

QSM has the potential to probe MR-invisible objects, based on the effect of their magnetic susceptibility on the nearby B0 field in MR-visible regions. However, the fundamental ability to map magnetic susceptibility of MR-invisible objects based on nearby B0 measurements has not yet been characterized. In this work, we address this question with phantom experiments and singular value decomposition analysis. Our results demonstrate that susceptibility measurement may be feasible in MR-invisible regions if the susceptibility distribution can be assumed to be homogeneous over the MR-invisible region of interest. However, susceptibility mapping of spatially-varying susceptibility distributions in MR-invisible regions is an inherently challenging problem.

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