p-space imaging: Where does the contrast come from?
Sina Straub 1 , Andreas Wetscherek 1 , Mark E. Ladd 1 , and Frederik B. Laun 1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany
The effect of p-space imaging is simulated for a voxel
filled with myelinated axons compared to a voxel with
homogeneous magnetization. P-space can be obtained by
sampling k-space with a standard gradient echo sequence
and applying additional gradients before the imaging
gradients. In the simulations, little to no difference
is observed between the MR signal of the voxel with
substructure and the one with homogeneous magnetization.
P-space MR experiments, however, showed partial volume
effects and signal enhancement in phase and magnitude
images that are indicative of subvoxel structure.
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