p-space imaging: Where does the contrast come from?

The effect of p-space imaging is simulated for a voxel filled with myelinated axons compared to a voxel with homogeneous magnetization. P-space can be obtained by sampling k-space with a standard gradient echo sequence and applying additional gradients before the imaging gradients. In the simulations, little to no difference is observed between the MR signal of the voxel with substructure and the one with homogeneous magnetization. P-space MR experiments, however, showed partial volume effects and signal enhancement in phase and magnitude images that are indicative of subvoxel structure.

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