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Abstract #3345

Lorentzian Fitting of the CEST Z-Spectra in Blood Red Cells

Shaokuan Zheng 1 , Guoxing Lin 2 , Zhongliang Zu 3 , Yansong Zhao 4 , and Matthew J Gounis 1

1 Department of Radiology, UMASS Medical School, Worcester, MA, United States, 2 Gustav H. Carlson School of Chemistry, Clark University, Worcester, MA, United States, 3 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 4 Philips Healthcare, Cleveland, OH, United States

In this study, we performed 1H NMR spectroscopy of red blood cells and subsequently applied Lorentzian fitting of the Z-spectrum, in order to distinguish between the Nuclear Overhauser Effect (NOE) signal and the CEST signal. Two different Lorentzian fitting methods were evaluated for the Z-spectrum acquired at different saturation powers. Three typical saturation powers of 0.54 uT, 2 uT and 4 uT were used to represent low, medium and high power level. We found that Lorentzian fitting method I has a good fitting for Z-spectra acquired at low saturation power and Lorentzian fitting method II has a good fitting for z-spectra acquired at both medium and high saturation power.

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