Abstract #3345
Lorentzian Fitting of the CEST Z-Spectra in Blood Red Cells
Shaokuan Zheng 1 , Guoxing Lin 2 , Zhongliang Zu 3 , Yansong Zhao 4 , and Matthew J Gounis 1
1
Department of Radiology, UMASS Medical
School, Worcester, MA, United States,
2
Gustav
H. Carlson School of Chemistry, Clark University,
Worcester, MA, United States,
3
Institute
of Imaging Science, Vanderbilt University, Nashville,
TN, United States,
4
Philips
Healthcare, Cleveland, OH, United States
In this study, we performed 1H NMR spectroscopy of red
blood cells and subsequently applied Lorentzian fitting
of the Z-spectrum, in order to distinguish between the
Nuclear Overhauser Effect (NOE) signal and the CEST
signal. Two different Lorentzian fitting methods were
evaluated for the Z-spectrum acquired at different
saturation powers. Three typical saturation powers of
0.54 uT, 2 uT and 4 uT were used to represent low,
medium and high power level. We found that Lorentzian
fitting method I has a good fitting for Z-spectra
acquired at low saturation power and Lorentzian fitting
method II has a good fitting for z-spectra acquired at
both medium and high saturation power.
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