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Abstract #3351

Combining CEST with CESL to differentiate slow exchanging pool from fast exchanging pool: mapping the concentration of Glutamate and Amides separately

Olivier E. Mougin 1 and Penny A Gowland 1

1 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Chemical Exchange Saturation Transfer (CEST) and Chemical Exchange Spin Locking (CESL) have different sensitivities to different exchanging pools. Here we present a simple method to separate overlapping pools such as APT and Glutamate based on a linear combination of signals from different CEST and CESL sequences. The method described here is directly applicable on clinical scanner, and should prove useful in quantification of fast exchanging proton pools

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