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Abstract #3427

PET attenuation correction for PET/MR by combining MR segmentation and selective-update joint estimation

Lishui Cheng 1 , Sangtae Ahn 1 , Dattesh Shanbhag 2 , Florian Wiesinger 3 , Sandeep Kaushik 2 , and Ravindra Manjeshwar 1

1 GE Global Research, Niskayuna, NY, United States, 2 GE Global Research, Bangalore, India, 3 GE Global Research, Munich, Germany

Attenuation correction is critical to accurate PET quantitation. In PET/MR, MR-based attenuation correction (MR-AC) has challenges in bone, air, lung and implant regions. To address the problem, we combined 1) a segmentation-based MR-AC method, which works well in soft-tissue regions, and 2) a selective-update joint estimation approach, which reconstructs both attenuation and activity from PET emission data, to resolve the attenuation in the challenging regions. The method was evaluated on clinical data from a PET/MR scanner with TOF information and it was demonstrated that the method can distinguish between abdominal air and spinal implant/bone regions, otherwise hidden in MR.

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