Abstract #3447
The Effect of Therapeutic Hypothermia on Cerebral Metabolism in Neonates with Hypoxic-Ischemic Encephalopathy
Jessica L Wisnowski 1 , Aaron J Reitman 1 , Tai-Wei Wu 2 , Jonathan M Chia 3 , Eugenia Ho 1 , Claire McLean 1 , Philippe Friedlich 1 , Ashok Panigrahy 4 , and Stefan Bluml 1,5
1
Children's Hospital Los Angeles/USC, Los
Angeles, CA, United States,
2
Chang
Gung Memorial Hospital, Lankou, Taiwan,
3
Philips
Healthcare, Cleveland, OH, United States,
4
Children's
Hospital of Pittsburgh, Pittsburgh, PA, United States,
5
Rudi
Schulte Research Institute, Santa Barbara, CA, United
States
MRS acquired during therapeutic hypothermia (TH) and
after re-warming in neonates with hypoxic-ischemic
encephalopathy demonstrated increased phosphocreatine
and lower glutamate and GABA during TH relative to after
rewarming. These in vivo data provide convergent
evidence that the neuroprotective mechanisms of TH
include decreased cerebral metabolic demand and
demonstrate that MRS is not only an important diagnostic
tool, but also may aid the development and evaluation of
neuroprotective therapies.
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