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Abstract #3447

The Effect of Therapeutic Hypothermia on Cerebral Metabolism in Neonates with Hypoxic-Ischemic Encephalopathy

Jessica L Wisnowski 1 , Aaron J Reitman 1 , Tai-Wei Wu 2 , Jonathan M Chia 3 , Eugenia Ho 1 , Claire McLean 1 , Philippe Friedlich 1 , Ashok Panigrahy 4 , and Stefan Bluml 1,5

1 Children's Hospital Los Angeles/USC, Los Angeles, CA, United States, 2 Chang Gung Memorial Hospital, Lankou, Taiwan, 3 Philips Healthcare, Cleveland, OH, United States, 4 Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 5 Rudi Schulte Research Institute, Santa Barbara, CA, United States

MRS acquired during therapeutic hypothermia (TH) and after re-warming in neonates with hypoxic-ischemic encephalopathy demonstrated increased phosphocreatine and lower glutamate and GABA during TH relative to after rewarming. These in vivo data provide convergent evidence that the neuroprotective mechanisms of TH include decreased cerebral metabolic demand and demonstrate that MRS is not only an important diagnostic tool, but also may aid the development and evaluation of neuroprotective therapies.

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