Abstract #3450
The effect of weight loss on brain microstructure in obese middle-aged women
Clifford Chan 1 , Heather Collins 1 , Patrick M O'Neil 2 , Joshua Brown 2 , Joseph A Helpern 1 , and Andreana Benitez 1
1
Department of Radiology and Radiological
Sciences, Medical University of South Carolina,
Charleston, South Carolina, United States,
2
Weight
Management Center, Department of Psychiatry and
Behavioral Sciences, Medical University of South
Carolina, Charleston, South Carolina, United States
Almost 40% of middle-aged adults in the US are obese and
are at 74% greater risk for developing dementia compared
to normal weight peers. A higher BMI has been associated
with atrophy of both gray and white matter, in regions
that preferentially degenerate with age and demonstrate
early pathological signs of dementing diseases. Although
these observations suggest that weight loss could be an
effective strategy for dementia prevention, no human
studies have directly tested whether weight loss is
associated with favorable brain changes measured through
diffusion MRI. This preliminary study reports changes in
DKI metrics before and after weight loss in obese
middle-aged women.
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