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Abstract #3474

Comprehensive assessment of the regional microstructure of the preterm human brain cerebral cortex using DKI and DTI

Tina Jeon 1 , Austin Ouyang 1 , Virendra Mishra 1 , Alejandra Perez 1 , Lina Chalak 2 , Jonathan Chia 3 , Muraleedharan Sivarajan 2 , Nancy Rollins 4 , and Hao Huang 1

1 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, United States, 2 Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas, United States, 3 Philips Medical Systems, Dallas, Texas, United States, 4 Department of Radiology, Children's Medical Center at Dallas, Dallas, Texas, United States

From the early 3rd trimester to around birth, the cerebral cortex undergoes rapid microstructural changes. Decreases of fractional anisotropy (FA) derived from DTI in cerebral cortex during this developmental period have been well documented in the literature. Mean kurtosis (MK), derived from diffusion kurtosis imaging (DKI), quantifies restricted water diffusion in the cerebral cortex and offers complementary information on cortical microstructural development. In this study, we aim to gain more comprehensive insight into regional microstructural changes of cerebral cortex by combining DKI and conventional DTI of the preterm human brains.

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