Optimized vascular signal reduction in contrast enhanced 3D T1 Turbo Spin Echo Imaging

Contrast enhanced MRI (CE-MRI)of the brain is routinely used to identify lesions and for staging treatment therapy. 3D T1-w turbo spin-echo (TSE) sequence provides a valuable contrast mechanism. However, identification of contrasting tissue can be hampered by neighboring enhancing vascular signal (VS). Typically, a preparation sequence is used to reduce the vascular signal. In this work, we study the application of vascular crushing gradients (VCG) along all axes integrated into the 3D T1 TSE sequence to reduce enhancing vasculature. Such a sequence is advantageous in reducing scan time as well as providing continuous reduction in VS. Evaluation of VS in CE-MRI images showed a large reduction in VS with a minor reduction in SNR after introduction of VCG.

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