Abstract #3480
Toward high resolution anatomical imaging of large ex vivo brain samples with specialized 9.4T RF coils
Shubharthi Sengupta 1 , Mark van Zandvoort 2 , Dean Paes 2 , Ralf Galuske 3 , Rainer Goebel 1 , and Alard Roebroeck 1
1
Dept. of Cognitive Neuroscience, Maastricht
University, Maastricht, Netherlands,
2
Maastricht
University, Netherlands,
3
Fachbereich
Biologie, Technische Universitt Darmstadt, Germany
Investigation of small human tissue samples at
ultra-high fields has involved the use of existing
preclinical gradient and RF coil systems to realise
important information about fundamental neuroanatomy at
the mesoscale. We test extending high resolution
post-mortem diffusion MRI to larger tissue samples by
using large-bore human 9.4T MRI system and as a proof of
concept designed and built a 9.4T coil for imaging
moderately sized specimens that fit a 4cm Petri dish. We
aim to achieve white and gray matter fiber orientational
modelling from diffusion MRI at 300um in a cat brain
sample, which would be difficult to achieve using a
larger coil designed for human in-vivo imaging.
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