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Abstract #3480

Toward high resolution anatomical imaging of large ex vivo brain samples with specialized 9.4T RF coils

Shubharthi Sengupta 1 , Mark van Zandvoort 2 , Dean Paes 2 , Ralf Galuske 3 , Rainer Goebel 1 , and Alard Roebroeck 1

1 Dept. of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2 Maastricht University, Netherlands, 3 Fachbereich Biologie, Technische Universitt Darmstadt, Germany

Investigation of small human tissue samples at ultra-high fields has involved the use of existing preclinical gradient and RF coil systems to realise important information about fundamental neuroanatomy at the mesoscale. We test extending high resolution post-mortem diffusion MRI to larger tissue samples by using large-bore human 9.4T MRI system and as a proof of concept designed and built a 9.4T coil for imaging moderately sized specimens that fit a 4cm Petri dish. We aim to achieve white and gray matter fiber orientational modelling from diffusion MRI at 300um in a cat brain sample, which would be difficult to achieve using a larger coil designed for human in-vivo imaging.

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