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Abstract #3482

In vivo quantification of human hippocampal subfields in health and in organic amnesia using 7.0-Tesla 0.4mm2 3-D fast spin echo imaging

Clive R Rosenthal 1 , Thomas D Miller 1 , Tammy W C Ng 2 , Stuart Golodetz 3 , Christopher Kennard 1 , and Penny A Gowland 4

1 Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Department of Anaesthesia, Univerisity College London Hospital, London, London, United Kingdom, 3 Computer Science, University of Oxford, Oxford, Oxfordshire, United Kingdom, 4 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Reliable in vivo identification of human hippocampal (Hc) subfields remains a significant challenge. Here, we quantified human Hc subfields along the transverse axis at an unprecedented resolution (0.4 x 0.4 x 0.1 mm). Subfield volumes in 12 healthy adults yielded distributions consistent with histological data, whereas volumes were significantly reduced in three adults with bilateral hippocampal amnesia. Dice indices were high, indicating that the protocol was suited to reliable delineation of Hc subfields in health and in disease. The results demonstrate that in vivo 3D-FSE 7.0-Tesla neuroimaging can be administered to test whether Hc pathology is manifest in specific subfields.

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