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Abstract #3486

Diffusion Tensor Tractography of Human Spinocerebellar, Cortico-Ponto-Cerebellar and Dentate-Rubro-Thalamo-Cortical Pathways

Khader M Hasan 1 , Zafer Keser 2 , Arash Kamali 3 , Nuray Yozbatiran 2 , and Gerard E Francisco 2

1 Diagnostic and Interventional Imaging, University of Texas Health Science Center, Houston, Texas, United States, 2 Physical Medicine and Rehabilitation, University of Texas Health Science Center and TIRR NeuroRecovery Research Center, Houston, Texas, United States, 3 Department of Diagnostic Radiology, Division of Neuroradiology, Johns Hopkins University, Maryland, United States

In this study, we demonstrate the feasibility of in vivo delineation and 3D reconstruction of the main cerebellar pathways using high resolution diffusion tensor imaging (DTI) data on 3.0 T in a systematic way. We also identified and quantified bilaterally each tract volume and its corresponding DTI scalar metrics. Although these tracts have been described previously, a clear deterministic tractography protocol to reconstruct all these tracts and their corresponding DTI attributes has not been reported.We believe that revealing the connections of cerebellum with extracerebellar structures is a crucial step in understanding underestimated roles of cerebellum.

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