A Novel Method of G-ratio Measurement in White Matter with Validation of Monte Carlo Simulation

The g-ratio is equal to the ratio between axon diameter and fiber diameter (axon plus myelin sheath). Previous studies have shown that g-ratio can be a potential biomarker for white matter that is sensitive to the process of demyelination and remyelination after disease, as well as sex differences in the brain development of adolescences. We propose a noninvasive way to estimate g-ratio. To validate the accuracies of our method, we simulate the effect of multi-component T2 and diffusion on g-ratio with a three-compartment Monte Carlo model.

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