Corticospinal tract diffusivity is related to motor cortex surface area in healthy controls
Niels Bergsland 1,2 , Maria Marcella Lagan 1 , Eleonora Tavazzi 1 , Francesca Baglio 1 , Paola Tortorella 1 , Matteo Caffini 2 , Mario Clerici 1 , Giuseppe Baselli 2 , and Marco Rovaris 1
IRCCS, Fondazione Don Gnocchi, Milan, MI,
di Elettronica, Informatica e Bioingegneria, Politecnico
di Milano, Milan, MI, Italy
The relationship between cortical morphology and
anatomically/functionally connected white matter tracts
has not been widely studied in healthy subjects. We used
FreeSurfer to reconstruct the primary motor cortex (PMC)
from 3D-T1 MRI. Diffusion tensor imaging was used to
assess measures of corticospinal tract (CST) integrity.
Controlling for age, sex and intracranial volume,
diffusivity coefficients within the CST were moderately
to strongly correlated with PMC surface area, but not
thickness nor curvature. The neural underpinnings of
these relationships remain to be elucidated.
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