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Abstract #3490

Corticospinal tract diffusivity is related to motor cortex surface area in healthy controls

Niels Bergsland 1,2 , Maria Marcella Lagan 1 , Eleonora Tavazzi 1 , Francesca Baglio 1 , Paola Tortorella 1 , Matteo Caffini 2 , Mario Clerici 1 , Giuseppe Baselli 2 , and Marco Rovaris 1

1 IRCCS, Fondazione Don Gnocchi, Milan, MI, Italy, 2 Dipartimento di Elettronica, Informatica e Bioingegneria, Politecnico di Milano, Milan, MI, Italy

The relationship between cortical morphology and anatomically/functionally connected white matter tracts has not been widely studied in healthy subjects. We used FreeSurfer to reconstruct the primary motor cortex (PMC) from 3D-T1 MRI. Diffusion tensor imaging was used to assess measures of corticospinal tract (CST) integrity. Controlling for age, sex and intracranial volume, diffusivity coefficients within the CST were moderately to strongly correlated with PMC surface area, but not thickness nor curvature. The neural underpinnings of these relationships remain to be elucidated.

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