Abstract #3505
Cortical thickness measurements with MPRAGE and MP2RAGE at 3T
Quentin Duch 1,2 , Parnesh Raniga 3 , Gary F. Egan 3 , Oscar Acosta 1 , Pierrick Bourgeat 2 , Vincent Dor 2 , Herv Saint-Jalmes 1 , and Olivier Salvado 2
1
LTSI, INSERM, Universit de Rennes 1,
Rennes, France,
2
CSIRO
Digital productivity Flagship, Australian e-Health
Research Centre, Herston, QLD, Australia,
3
Monash
Biomedical Imaging, Monash University, VIC, Australia
Cortical thickness is a clinical biomarker of
neurodegenerative diseases and ageing and is often
included in clinical studies. Cortical thickness
estimation (CTE) is commonly estimated using
T1-weighted, MPRAGE sequence. The recent MP2RAGE
sequence has been proposed with lower intensity
inhomogeneity and increased tissue contrast. This
abstract compares CTE with MPRAGE and MP2RAGE using a
test-retest experiment. A bias between MPRAGE and
MP2RAGE was found and could be corrected by a new
partial volume model. MP2RAGE was found to be more
reproducible than MPRAGE and should therefore be
considered for measuring cortical thickness in clinical
studies. MP2RAGE was found to be more reproducible than
CTE with MPRAGE.
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