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Abstract #3505

Cortical thickness measurements with MPRAGE and MP2RAGE at 3T

Quentin Duch 1,2 , Parnesh Raniga 3 , Gary F. Egan 3 , Oscar Acosta 1 , Pierrick Bourgeat 2 , Vincent Dor 2 , Herv Saint-Jalmes 1 , and Olivier Salvado 2

1 LTSI, INSERM, Universit de Rennes 1, Rennes, France, 2 CSIRO Digital productivity Flagship, Australian e-Health Research Centre, Herston, QLD, Australia, 3 Monash Biomedical Imaging, Monash University, VIC, Australia

Cortical thickness is a clinical biomarker of neurodegenerative diseases and ageing and is often included in clinical studies. Cortical thickness estimation (CTE) is commonly estimated using T1-weighted, MPRAGE sequence. The recent MP2RAGE sequence has been proposed with lower intensity inhomogeneity and increased tissue contrast. This abstract compares CTE with MPRAGE and MP2RAGE using a test-retest experiment. A bias between MPRAGE and MP2RAGE was found and could be corrected by a new partial volume model. MP2RAGE was found to be more reproducible than MPRAGE and should therefore be considered for measuring cortical thickness in clinical studies. MP2RAGE was found to be more reproducible than CTE with MPRAGE.

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