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Abstract #3511

Association of Hippocampal Shape with Childrens Cognitive Performance Analyzed Using Radial-Distance Mapping and Two Non-Rigid Registration Methods

Peter T Fwu 1 , Elysia P Davis 2 , Claudia Buss 2 , Muqing Lin 1 , Kevin Head 2 , Curt A Sandman 2 , and Min-Ying Su 1

1 Tu&Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States, 2 Women and Childrens Health and Well-Being Project, Department of Psychiatry & Human Behavior, University of California, Irvine, CA, United States

Hippocampal volume and shape analysis was applied to 103 children (6-10 years old) to evaluate the association with their cognitive performance in different domains (learning, memory, recognition). Radial distance mapping and two non-rigid registration methods were applied to analyze shape based on the deformation matrix. Results obtained using these three different methods were consistent, and they suggest that different hippocampal regions are associated with different cognitive performance tasks. Analyses done separately in males and females showed similar results. None of the volumetric measurements revealed significant correlations, suggesting that shape analysis may provide a more sensitive tool for subregional analysis.

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