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Abstract #3517

Magnetic resonance elastography in the brain: an in silico study on the influence of cranial anatomy

Deirdre M McGrath 1,2 , Nishant Ravikumar 1 , Alejandro F Frangi 1 , Iain D Wilkinson 2 , and Zeike A Taylor 1

1 CISTIB, Center for Computational Imaging & Simulation Technologies in Biomedicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Magnetic resonance elastography (MRE) of the brain is currently being evaluated as a biomarker of neurodegenerative disease. However, MRE-measured biomechanical data for healthy brain varies widely. Therefore, it is important to assess the possible impact of other factors such as variable brain geometry and cranial anatomy. Finite element model simulations of MRE are carried out on brain meshes including the falx cerebri and tentorium cerebelli membranes to examine the role these structures play in wave transmission and reflection and how they may influence the MRE-measured displacement fields and inversion reconstructions of brain biomechanics.

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