Abstract #3517
Magnetic resonance elastography in the brain: an in silico study on the influence of cranial anatomy
Deirdre M McGrath 1,2 , Nishant Ravikumar 1 , Alejandro F Frangi 1 , Iain D Wilkinson 2 , and Zeike A Taylor 1
1
CISTIB, Center for Computational Imaging &
Simulation Technologies in Biomedicine, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom,
2
Academic
Radiology, University of Sheffield, Sheffield, South
Yorkshire, United Kingdom
Magnetic resonance elastography (MRE) of the brain is
currently being evaluated as a biomarker of
neurodegenerative disease. However, MRE-measured
biomechanical data for healthy brain varies widely.
Therefore, it is important to assess the possible impact
of other factors such as variable brain geometry and
cranial anatomy. Finite element model simulations of MRE
are carried out on brain meshes including the falx
cerebri and tentorium cerebelli membranes to examine the
role these structures play in wave transmission and
reflection and how they may influence the MRE-measured
displacement fields and inversion reconstructions of
brain biomechanics.
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