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Abstract #3520

Investigation of the Confounding Effects of Vasculature and Metabolism on Computational Anatomy Studies

Christine Lucas Tardif 1 , Christopher John Steele 1 , Pierre-Louis Bazin 1 , Arno Villringer 1 , and Claudine Jolle Gauthier 1,2

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany, 2 Department of Physics, Concordia University, Montreal, Quebec, Canada

T1 maps were acquired under normal, hypercapnic (increased CO2) and hyperoxic (increased O2) breathing conditions to investigate the confounding effects of dissolved oxygen, blood flow and blood volume on computational anatomy studies. We show a decrease in T1 during hypercapnia and hyperoxia, as well as an increase in cortical thickness during hypercapnia. These biases should be taken into account when interpreting MR-based structural plasticity studies of ageing and learning, for instance.

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