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Abstract #3568

Clinical correlations of fornix are disparate in first episode and chronic patients with schizophrenia: A tract-based diffusion spectrum imaging analysis

Yan-Lin Chiu 1,2 , Su-Chun Huang 2 , Chih-Min Liu 3 , Tzung-Jeng Hwang 3 , Hai-Gwo Hwu 3 , Yung-Chin Hsu 2 , Yu-Chun Lo 2 , Yu-Jen Chen 2 , and Wen-Yih Isaac Tseng 2,4

1 School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 2 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan, 3 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, 4 Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

In the present study we found that fornix is an important tract when investigating the white matter microstructural changes of schizophrenia. Decreased GFA values of bilateral fornix were found in patients group. Moreover, the correlations of clinical symptoms and GFA of fornix showed entirely different patterns between FE and chronic patients. We hypothesize that the phenomenon may be a complex interaction of medication-related changes and natural disease progress. For future works, we plan to do long term follow-up with detailed medication history of the patients to ascertain the effects of antipsychotic medications.

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