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Abstract #3584

The dynamics of cerebrovascular reactivity shown with transfer function analysis

James Duffin 1,2 , Olivia Sobczyk 3 , David J Mikulis 3,4 , and Joseph A Fisher 1,2

1 Department of Physiology, University of Toronto, Toronto, Ontario, Canada, 2 Department of Anaesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada, 3 Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada, 4 Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, Ontario, Canada

The cerebrovascular reactivity (CVR) to a stimulus assesses the health of the cerebovasculature. When measured with MRI, the resulting CVR values for each voxel can be displayed using a color scale mapped onto the corresponding anatomical scan to generate CVR maps showing the distribution of the vascular responses. However, such CVR maps estimate only the magnitude, and do not indicate the time course of the response; whether rapid or slow. Transfer function analysis provides not only the magnitude of the response but also the phase, an indicator of the response dynamics, as well as a measure of the fidelity with which the response follows the stimulus.

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