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Abstract #3597

Neuroplasticity for spontaneous functional recovery after neonatal hypoxic ischemic injury

Won Beom Jung 1,2 , Geun Ho Im 1,2 , Sun Young Chae 3 , Yong Hee Han 1,2 , and Jung Hee Lee 1,3

1 Department of Radiology Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, 2 Center for Molecular and Cellular Imaging Samsung Biomedical Research Institute, Seoul, Korea, 3 Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University, Seoul, Korea

In this study, we examined the functional and anatomical brain changes in perinatal hypoxic ischemic injured rat brain with BOLD-fMRI, DTI and rs-fMRI. HI injured brains were observed with the the widespread sensory-motor related areas on intact forelimb, weakly evoked brain activation on impaired forelimb, intra-hemispheric track rewiring and enhanced intra-connectivity in cingulate cortex areas compared with sham-operated brains. In addition, impared forelimb show the behavioral perfomance although not complete. We believe that brain modulations in HI induced rats are the neuralplasticity for spontaneous recovery to compensate for functional loss.

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