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Abstract #3609

Quantitative MRI of Brain Perivascular Space

Kejia Cai 1,2 , Rongwen Tain 1,2 , Sandhitsu Das 3 , Frederick C. Damen 1,2 , Yi Sui 2,4 , Shika Dammala 5 , Paul Yushkevich 3 , Tibor Valyi-Nagy 6 , Mark A. Elliott 3 , and X. Joe Zhou 1,2

1 Radiology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States, 2 Center for MR Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States, 3 Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 4 Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States, 5 Biology, University of Illinois at Chicago, Chicago, Illinois, United States, 6 Neuropathology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

Although dilated perivascular spaces, also called the Virchow-Robin spaces (VRS), are found to be associated with many conditions, including aging, dementia, cerebral amyloid angiopathy, neuroinflammation, and neoplasm, it is necessary to determine whether dilated VRS is a normal variant or related to a disease process. Conventionally, such determination is mainly based on the subjective observations of the number, size and shape of the observable VRS in MR images. In this study, we developed an objective image analyzing method to quantify the brain VRS density in AD patients and age-matched healthy controls.

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