Abstract #3609
Quantitative MRI of Brain Perivascular Space
Kejia Cai 1,2 , Rongwen Tain 1,2 , Sandhitsu Das 3 , Frederick C. Damen 1,2 , Yi Sui 2,4 , Shika Dammala 5 , Paul Yushkevich 3 , Tibor Valyi-Nagy 6 , Mark A. Elliott 3 , and X. Joe Zhou 1,2
1
Radiology, College of Medicine, University
of Illinois at Chicago, Chicago, Illinois, United
States,
2
Center
for MR Research, College of Medicine, University of
Illinois at Chicago, Chicago, Illinois, United States,
3
Radiology,
School of Medicine, University of Pennsylvania,
Philadelphia, PA, United States,
4
Bioengineering,
University of Illinois at Chicago, Chicago, Illinois,
United States,
5
Biology,
University of Illinois at Chicago, Chicago, Illinois,
United States,
6
Neuropathology,
College of Medicine, University of Illinois at Chicago,
Chicago, Illinois, United States
Although dilated perivascular spaces, also called the
Virchow-Robin spaces (VRS), are found to be associated
with many conditions, including aging, dementia,
cerebral amyloid angiopathy, neuroinflammation, and
neoplasm, it is necessary to determine whether dilated
VRS is a normal variant or related to a disease process.
Conventionally, such determination is mainly based on
the subjective observations of the number, size and
shape of the observable VRS in MR images. In this study,
we developed an objective image analyzing method to
quantify the brain VRS density in AD patients and
age-matched healthy controls.
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