Dixon Fat Suppression for Off-resonant Water Imaging of Superparamagnetic Iron Oxide Nanoparticles

The aim of this project is to improve and validate a fat saturation technique for MR imaging with magnetic nanoparticles (MNPs). Inversion Recovery with ON-resonant water suppression (IRON) has been shown to produce reliable positive contrast images with MNPs. The most common fat saturation technique in combination with IRON is a spectrally selective pre-saturation pulse (SPIR). We used a two echo Dixon method instead of SPIR to achieve fat saturation in a phantom study. The Dixon method demonstrated superior fat suppression ability compared to SPIR while achieving the same positive contrast of MNP rich areas of the phantom.

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