Simultaneous quantification of intravascular blood T 1 and T 2 with multiple-readout TRUST (mTRUST)

Simultaneous measurement of intravascular blood T ₁ and T ₂ is a promising approach for fast, accurate quantification of whole-brain venous oxygen saturation (Y _v ), as the T ₁ values can be used to determine hematocrit, which is needed to convert measured T ₂ to Y _v . We describe a modification of the recently developed TRUST T ₂ -quantification method, with addition of multiple EPI readouts (mTRUST) to allow concurrent measurement of T ₁ . mTRUST was applied in four subjects, demonstrating good precision for T ₁ and T ₂ estimation. T ₁ values were slightly lower than recent literature, potentially due to incomplete inversion of blood present in the later EPI readouts.

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