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Abstract #3696

Quantitative 19 F MR Molecular Imaging with B 1 -Mapping Compensation

Matthew Goette 1,2 , Shelton Caruthers 1 , Gregory Lanza 1 , and Samuel Wickline 1

1 Cardiology, Washington University in St. Louis, St. Louis, MO, United States, 2 Pediatric Radiology, Texas Children's Hospital, Houston, TX, United States

This study presents a strategy to more accurately quantify the sparse 19 F signal from lower case Greek alpha lower case Greek nu lower case Greek beta 3 integrin targeted perfluorocarbon nanoparticle emulsions with a 1 H image-based actual flip angle B 1 -mapping correction to the 19 F and 1 H images, acquired with a simultaneous dual-frequency ultra-short echo time balanced steady state free precession sequence, in a phantom and an in vivo setting using a VX2 tumor model implanted into rabbits.

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