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Abstract #3699

PRAIRIE: Accelerating MR Parameter Mapping Using Kernel-Based Manifold Learning and Pre-Imaging

Yihang Zhou 1 , Chao Shi 1 , Yanhua Wang 1 , Jingyuan Lyu 1 , and Leslie Ying 1,2

1 Department of Electrical Engineering, State University of New York at Buffalo, Buffalo, NY, United States, 2 Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, United States

In this study, a novel reconstruction method using kernel-based manifold learning and regularized pre-imaging is proposed to accelerate the MR parameter mapping. The parametric-weighted image at a specific time point is assumed to lie in a low-dimensional manifold and is reconstructed individually. The low-dimensional manifold is learned from the training images generated by the parametric model. The underlying optimization problem is solved using kernel trick and split Bregman iteration algorithm. Our preliminary result demonstrated that the proposed method is able to accurately recover the T2 map at high reduction factors when the conventional compressed sensing methods with linear models fail.

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