Evaluation of the Errors in the Measured Dynamic Contrast Enhancement with TWIST View Sharing Using a Novel Simulation Strategy
Yuan Le 1 , Marcel Dominik Nickel 2 , Randall Kroeker 3 , Christian Geppert 2 , Bruce Spottiswoode 3 , and Chen Lin 1
Radiology and Imaging Science, Indiana
University School of Medicine, Indianapolis, IN, United
Healthcare, Erlangen, Bavaria, Germany,
Medical Solutions, NC, United States
In order to investigate the representation of complex
tumors when using modern, view sharing MRI sequences
such as TWIST, dynamic contrast-enhanced TWIST raw data
were generated from static background and a fractal
tumor phantom raw data scaled with an enhancement model.
Our results show that, for typical spatial resolution in
clinical breast DCE-MRI, TWIST parameters of pA=20%-25%
and pB=33% provided an enhancement measurement with
lowest RMS error. The measured shape irregularity of the
tumor changed in a less predictable way, however, which
should be taken into consideration in the texture
analysis of the images.
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