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Abstract #3810

Radiation induced hypoxia in TRAMP tumor detected using BOLD MRI

Yu-Chun Lin 1 , Gigin Lin 1 , Chun-Chieh Wang 2 , and Jiun-Jie Wang 3

1 Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Linkou, Taiwan, Taiwan, 2 Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan, 3 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Yaoyuan, Taiwan

This study monitored the changes of microvasculature and hypoxia after radiotherapy in TRAMP tumor using carbogen challenging BOLD MRI. A single dose irradiation was delivered in peripheral half of the tumor. The BOLD response to carbogen in the irradiated portion decreased compared with the non-irradiated portion. The immunohistochemistry images of CD31 and pimonidazole showed less hypoxia in the irradiated portion, while a trend of acute hypoxia in the non-irradiated region was noticed to shift to chronic hypoxia in the irradiated region. Carbogen-challenging BOLD MRI can be used to detect the hypoxic change within a tumor in response to radiotherapy

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