Abstract #3810
Radiation induced hypoxia in TRAMP tumor detected using BOLD MRI
Yu-Chun Lin 1 , Gigin Lin 1 , Chun-Chieh Wang 2 , and Jiun-Jie Wang 3
1
Department of Diagnostic Radiology, Chang
Gung Memorial Hospital, Linkou, Taiwan, Taiwan,
2
Department
of Radiation Oncology, Chang Gung Memorial Hospital,
Linkou, Taiwan,
3
Department
of Medical Imaging and Radiological Sciences, Chang Gung
University, Yaoyuan, Taiwan
This study monitored the changes of microvasculature and
hypoxia after radiotherapy in TRAMP tumor using carbogen
challenging BOLD MRI. A single dose irradiation was
delivered in peripheral half of the tumor. The BOLD
response to carbogen in the irradiated portion decreased
compared with the non-irradiated portion. The
immunohistochemistry images of CD31 and pimonidazole
showed less hypoxia in the irradiated portion, while a
trend of acute hypoxia in the non-irradiated region was
noticed to shift to chronic hypoxia in the irradiated
region. Carbogen-challenging BOLD MRI can be used to
detect the hypoxic change within a tumor in response to
radiotherapy
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