Abstract #3823
In vivo MRI-based 3-D Printed Molds and Individualized Tissue Sectioning Apparatuses Improve MRI-Histopathologic Co-Registration in Brain Cancer Patients
Alexander E. Salmon 1 , Brian J. Pellatt 2 , Nikolai J. Mickevicius 3 , Elizabeth J. Cochran 4 , and Peter S. LaViolette 5
1
Neuroscience, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Medical
College of Wisconsin, Milwaukee, WI, United States,
3
Biophysics,
Medical College of Wisconsin, Milwaukee, WI, United
States,
4
Pathology,
Medical College of Wisconsin, Milwaukee, WI, United
States,
5
Radiology,
Medical College of Wisconsin, Milwaukee, WI, United
States
Precise co-registration of brain tissue and medical
imaging is critical for validation of novel imaging
biomarkers. Brain tissue distortion during fixation and
traditional brain sectioning techniques may complicate
co-registration. To prevent tissue distortion, a
clinical MRI-based mesh mold was 3D-printed for use
during fixation. To obtain representative axial cuts, an
individualized tissue sectioning apparatus was designed
from a high resolution clinical scan and the slice
profile of 6.5mm images. After sectioning, consistency,
and co-registration error was analyzed by AFNI. Using a
layer resolution of 0.40mm, printing cost for each brain
was approximately $61 and printing duration was
approximately 38 hours.
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