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Abstract #3825

Monitoring gas-induced haemodynamic changes in the breast with BOLD contrast

Tess Catherwood 1 , Andrew Patterson 1 , Martin Graves 1 , Reem Bedair 1 , Roie Manavaki 1 , Mary McLean 2 , John Griffiths 2 , and Fiona Gilbert 1

1 Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom, 2 Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom

BOLD contrast MRI with hyperoxic gas challenge may provide a biomarker of breast tumour oxygenation and vascular function, with the potential to predict treatment response. This study measured the strength of BOLD response to carbogen-light (2% CO 2 ) interleaved with medical air and oxygen, compared to an all-air control, in six healthy volunteers. Carbogen-light was effective in inducing a measurable BOLD effect with respect to background physiological noise, without the respiratory discomfort often reported with 5% CO 2 mixtures. In general carbogen-light versus oxygen induced a larger response, consistent with the opposing vasomodulatory effects of these two stimuli.

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