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Abstract #3828

Evaluation of Benign and High-Risk, Nonmalignant Breast Lesions, assessed as False-Positive at Contrast-Enhanced (CE) MRI using DW imaging and CE MR Imaging Features

Sunitha B Thakur 1 , Jung Hun Oh 2 , Milans Soledad 2 , Harini Veeraraghavan 2 , Merlin M Gnanasigamani 2 , Elizabeth J Sutton 2 , Joseph O Deasy 2 , and Elizabeth A Morris 2

1 Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2 Memorial Sloan Kettering Cancer Center, NY, United States

Lesions that are classified high-risk typically require complete surgical excision; a procedure that is expensive and can cause anxiety and morbidity. Therefore, the ability to distinguish between lesions, especially to differentiate the high-risk benign group from other benign lesions would be extremely helpful in a clinical setting. We conducted this study in order to evaluate the imaging characteristics of non-malignant lesions and classify them using (i) apparent diffusion coefficient (ADC) values, (ii) morphological and (iii) texture-based image features derived from contrast enhanced magnetic resonance imaging. We used 3.0T MRI data from 111 women and found that lower ADC values appear to correlate with high-risk breast lesions. This study is useful because it probes the concept of distinguishing not just between malignant and benign lesions but goes further to classify benign lesions into subgroups that could be treated differently at the clinical level.

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