Investigation of reduced FOV CEST in probing prostate cancer

We investigate the use of a novel reduced FOV CEST method that allows us to zoom in the prostate region that helps delineating the tumor region from the benign region and improves accuracy in grading using CEST. The use of reduced FOV CEST in prostate was validated by comparing the APT map and MTRasym to those obtained using normal CEST, highly consistent results were obtained despite its lower intrinsic SNR. Reduced FOV CEST has the advantage of revealing the heterogeneity of the prostate, which may be difficult due to the constrained portion of the prostate region in normal FOV image.

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