Saturation duration and power optimization for APT MRI of prostate cancer
Harsh K Agarwal 1,2 , Jochen Keupp 3 , Marcelino Bernardo 2 , Baris Turkbey 2 , and Peter L Choyke 2
Philips Research NA, Briarcliff Manor, New
York, United States,
Institutes of Health, Bethesda, MD, United States,
Research Laboratories, Hamburg, Germany
Amide proton transfer (APT) MRI has been shown to
localize and stage prostate. However there are multiple
parameters such as saturation power and saturation
duration that affect the APT MRI contrast. In this
abstract we have shown that MTR asymmetry increased with
the decrease in the pulse duration. Also the peak of MTR
asymmetry shifted with the change in saturation power.
However spurious MTR was observed over prostate
especially in peripheral zone which could be due to the
incoherent motion such as rectal spasm.
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