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Abstract #3863

DCE-MRI kinetic model and curve pattern analyses for predicting response and survivals in osteosarcoma patients

Junyu Guo 1 and Wilburn E. Reddick 1

1 Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, United States

This study investigated two DCE-MRI data analysis methods for evaluating response to treatment and prognosis of event-free-survival (EFS) and overall-survival in 42 patients with osteosarcoma. In two methods, eight parameters and their absolute-difference (ABD) between two neighboring time points were assessed for the role of predicting clinical results. Three ABD parameters before week5 could potentially predict response. The CPA parameter lower case Greek beta lower case Greek tau on Day5 is the potential prognostic factor for EFS. Four ABD parameters before week5 are potential prognostic factors for overall-survival. All results show that two DCE-MRI analysis methods could provide valuable predictive information for clinical outcomes.

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