Abstract #3874
Dynamic Contrast Enhanced Magnetic Resonance Imaging Evaluates Therapeutic Mechanism of nab-Paclitaxel in Pancreatic Cancer Patient Derived Xenograft Mouse Models.
Hyunki Kim 1 , Sharon Samuel 1 , Marie Warren 1 , Guihua Zhai 1 , William Grizzle 1 , Denise Oelschlager 1 , Pedro Lopez-Casas 2 , Manuel Hidalgo 2 , Joy Kovar 3 , Kurt Zinn 1 , and Donald Buchsbaum 1
1
University of Alabama at Birmingham,
Birmingham, AL, United States,
2
Spanish
National Cancer Research Center, Madrid, Spain,
3
LI-COR
Biosciences, Nebraska, United States
Dynamic contrast enhanced magnetic resonance imaging
(DCE-MRI) was employed to identify the therapeutic
mechanism of nab-paclitaxel in pancreatic cancer patient
derived xenograft mouse models. DCE-MRI demonstrated
that nab-paclitaxel did not significantly increase the
microvascular perfusion in tumor xenografts for 3 weeks
of nab-paclitaxel treatment, although gemcitabine did.
Also, histologic analysis showed that tumor stroma was
not significantly reduced by nab-paclitaxel, but high
tumor retention of fluorophore labeled nab-paclitaxel
was observed. Therefore the significant clinical
benefits of nab-paclitaxel may result from its effective
delivery into tumors in pancreatic cancer.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
