Abstract #3905
Auditory Cortex Modulates the Midbrain Response Selectivity to Behaviorally Relevant Sounds
Jevin W. Zhang 1,2 , Patrick P. Gao 1,2 , Shu-Juan Fan 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong SAR, China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong SAR, China,
3
Center
for Neural Science, New York University, New York, NY,
United States
The auditory cortex (AC) is the source of one of the
largest inputs to the inferior colliculus (IC). Normal
IC exhibits stronger BOLD response to forward
vocalizations than to the temporally inverted one. But
this responses selectivity to behaviorally relevant
sound requires AC inputs. After bilateral AC ablation,
the BOLD response difference between the two
vocalizations in the IC was diminished. In the
unilateral (right side) AC ablation animals, the BOLD
response difference between the two vocalizations in the
ablation (right) side was negligible while the
contralateral (left) ECIC still showed a stronger
response to the forward vocalization.
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