Abstract #3907
Auditory and Visual Cortices Differentially Modulate Auditory Responses in the Midbrain
Patrick P. Gao 1,2 , Jevin W. Zhang 1,2 , Shu-Juan Fan 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong,
HKSAR, China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, HKSAR, China,
3
Center
for Neural Science, New York University, New York, NY,
United States
The cortex is commonly thought of as the site at which
ascending projections from all sensory modalities are
integrated, yet cortical feedback to subcortical nuclei
modulates early information processing. Here, we
demonstrate that descending inputs from both auditory
and visual cortex are integrated in the auditory
midbrain. Using BOLD fMRI to measure sound-evoked
responses throughout the auditory midbrain, we show that
auditory cortical input normally suppresses the gain of
midbrain response, while visual cortical input increases
the gain. Our results demonstrate the large-scale
influence of cortical projections from more than one
sensory modality, demonstrating that while ascending
integration occurs in cortex, descending integration
occurs in the brainstem.
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