Abstract #3909
Dose-dependent effects of sevoflurane on temporal distribution of BOLD responses to somatosensory stimulation in rats
Tomokazu Tsurugizawa 1,2 , Yukari Takahashi 1 , Akihiko Kitamura 1,3 , and Fusao Kato 1
1
Jikei University School of Medicine, Tokyo,
Japan,
2
NeuroSpin/CEA,
Gif-sur-Yvette, Essone, France,
3
Ajinomoto
Co. Inc., Kawasaki, Japan
We aimed to investigate the dose-dependence of
sevoflurane on BOLD responses in the upper layer (layer
1-3) and in the lower layer (layer 4-6) of the
somatosensory cortex to electrical stimulation in the
hindpaw. The BOLD responses in the upper layer were
greater than those in the lower layer. The estimation of
hemodynamic response indicates that time-courses of BOLD
responses were dependent on the concentration of
sevoflurane, indicating the disturbance of neurovascular
coupling by sevoflurane dos-dependently.
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