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Abstract #3909

Dose-dependent effects of sevoflurane on temporal distribution of BOLD responses to somatosensory stimulation in rats

Tomokazu Tsurugizawa 1,2 , Yukari Takahashi 1 , Akihiko Kitamura 1,3 , and Fusao Kato 1

1 Jikei University School of Medicine, Tokyo, Japan, 2 NeuroSpin/CEA, Gif-sur-Yvette, Essone, France, 3 Ajinomoto Co. Inc., Kawasaki, Japan

We aimed to investigate the dose-dependence of sevoflurane on BOLD responses in the upper layer (layer 1-3) and in the lower layer (layer 4-6) of the somatosensory cortex to electrical stimulation in the hindpaw. The BOLD responses in the upper layer were greater than those in the lower layer. The estimation of hemodynamic response indicates that time-courses of BOLD responses were dependent on the concentration of sevoflurane, indicating the disturbance of neurovascular coupling by sevoflurane dos-dependently.

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