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Abstract #3911

Accelerated Neonatal fMRI using Multiband EPI

Anthony N. Price 1,2 , Lucilio Cordero-Grande 1,2 , Shaihan J. Malik 1,2 , Maryam Abaei 1 , Tomoki Arichi 1 , Emer J. Hughes 1 , Daniel Rueckert 3 , A. David Edwards 1 , and Joseph V. Hajnal 1,2

1 Centre for the Developing Brain, King's College London, London, United Kingdom, 2 Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 3 Biomedical Image Analysis Group, Imperial College London, London, United Kingdom

Simultaneous multi-slice EPI acquisitions using multiband (MB) excitation have recently been demonstrated to provide high resolution fMRI data with significantly reduced acquisition time, sufficient enough to directly determine cardiac and respiratory influences from spontaneous activation in the brain. These have mainly been applied to adult subjects, but here we demonstrate MB EPI applied to preterm infants with cardiac rates exceeding 160 bpm. Resting state fMRI data collected with MB factors of 9 demonstrate it is possible to distinguish the neonatal cardiac physiology from activations in resting state networks.

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