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Abstract #3922

Method for epileptogenic focus localization using BOLD signal complexity analysis

Vnia Tavares 1 , Andr Santos Ribeiro 1,2 , Carlos Capela 3 , Lus Cerqueira 4 , and Hugo Alexandre Ferreira 1

1 Institute of Biophysics and Biomedical Engineering, Faculy of Sciences of the University of Lisbon, Lisboa, Portugal, 2 Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom, 3 Department of Neurology, Centro Hospitalar Lisboa Central, Lisbon, Portugal, 4 Department of Neuroradiology, Centro Hospitalar Lisboa Central, Lisbon, Portugal

A method for localizing the epileptogenic focus from functional magnetic resonance imaging data was developed. For that purpose a bi-dimensional temporal clustering analysis was used to identify potential epileptogenic foci. Then, the complexity of the corresponding BOLD signals was analyzed to identify the most probable focus. Complexity analysis comprised the use of a modified multiscale entropy analysis algorithm and the detrended fluctuation analysis algorithm. Results showed that this method is able to localize epileptogenic tissue in agreement with clinical knowledge. Results also showed that the epileptogenic foci influence the dynamics of related brain regions within epileptic networks.

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