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Abstract #3931

Change of Venous Susceptibility upon Visual Activation: 3D Multi-echo GRE vs. GRE-EPI Functional QSM

PINAR SENAY ZBAY 1,2 , Cristina Rossi 1 , Geoffrey Warnock 3 , Felix Kuhn 3 , Klaas Paul Prssmann 2 , and Daniel Nanz 1

1 Department of Radiology, University Hospital Zrich, Zrich, Switzerland, 2 Institute of Biomedical Engineering, ETH Zrich, Zrich, Switzerland, 3 Department of Nuclear Medicine, University Hospital Zrich, Zrich, Switzerland

This study compared BOLD- and QSM-based neuronal activation patterns and changes of venous magnetic susceptibility under visual-stimulation as observed in data acquired with (i) traditional repeated fast whole-brain covering 2D GRE-EPI scans versus with (ii) single 3D-GRE scans. T-score-maps from statistical parametric mapping of the EPI-acquired fQSM time-series-data and difference maps (ON-OFF) for both EPI-fQSM and 3D-GRE-fQSM are presented. Image quality of 3D-GRE-fQSM and its difference-map were superior to corresponding EPI-QSM data. 3D-GRE-fQSM detected larger reduction of venous magnetic susceptibility upon visual stimulation than EPI-fQSM. 3D-GRE-fQSM might have a potential for studies with a focus on the venous vessel tree.

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