Abstract #3940
High Resolution Cerebral Metabolic Rate of Oxygen (CMRO2) using Quantitative Susceptibility Mapping (QSM) and an Oxygen Extraction Fraction (OEF) Constraint
Jingwei Zhang 1,2 , Thanh D. Nguyen 2 , Pascal Spincemaille 2 , Tian Liu 3 , Dong Zhou 2 , Ajay Gupta 2 , and Yi Wang 1,2
1
Biomedical Engineering, Cornell University,
New York, New York, United States,
2
Radiology,
Weill Cornell Medical College, New York, New York,
United States,
3
Medimagemetric, LLC, New York,
United States
Quantitative susceptibility mapping (QSM) is
advantageous over R2* for determining deoxyhemoglobin
concentration from gradient echo MRI data. QSM can be
used for quantitative CMRO2 mapping using pre- and post-
caffeine challenge, a procedure much simpler than that
required by R2*. In general, CMRO2 is sensitive to the
poor SNR inherent in MRI based deoxyhemoglobin
measurements. One of the noise consequence is to cause
the estimated OEF exceed its physiological range. To
overcome this limitation, we propose to solve for CMRO2
by constraining OEF within its physiological limit.
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