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Abstract #3940

High Resolution Cerebral Metabolic Rate of Oxygen (CMRO2) using Quantitative Susceptibility Mapping (QSM) and an Oxygen Extraction Fraction (OEF) Constraint

Jingwei Zhang 1,2 , Thanh D. Nguyen 2 , Pascal Spincemaille 2 , Tian Liu 3 , Dong Zhou 2 , Ajay Gupta 2 , and Yi Wang 1,2

1 Biomedical Engineering, Cornell University, New York, New York, United States, 2 Radiology, Weill Cornell Medical College, New York, New York, United States, 3 Medimagemetric, LLC, New York, United States

Quantitative susceptibility mapping (QSM) is advantageous over R2* for determining deoxyhemoglobin concentration from gradient echo MRI data. QSM can be used for quantitative CMRO2 mapping using pre- and post- caffeine challenge, a procedure much simpler than that required by R2*. In general, CMRO2 is sensitive to the poor SNR inherent in MRI based deoxyhemoglobin measurements. One of the noise consequence is to cause the estimated OEF exceed its physiological range. To overcome this limitation, we propose to solve for CMRO2 by constraining OEF within its physiological limit.

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