Abstract #3942
Resting-state alterations in EEG-fMRI coupling in adults with attention-deficit/hyperactivity disorder
Lars Michels 1,2 , Steffen Bollmann 2 , Diego Manuel Baur 2 , Anthony Schlpfer 3 , Maya Schneebeli 3 , Carmen Ghisleni 2 , Peter Klaver 2,4 , Daniel Brandeis 3,5 , and Ruth O'Gorman 2
1
Institute of Neuroradiology, University
Hospital Zurich, Zurich, Zurich, Switzerland,
2
Center
for MR-Research, University Childrens Hospital, Zurich,
Zurich, Switzerland,
3
Department
of Child and Adolescent Psychiatry University of Zrich,
University of Zurich, Zurich, Switzerland,
4
Institute
of Psychology, University of Zurich, Zurich,
Switzerland,
5
Department
of Child & Adolescent Psychiatry and Psychotherapy,
Central Institute of Mental Health Ma, Medical Faculty
Mannheim / Heidelberg University, Mannheim, Mannheim,
Germany
Attention-deficit/hyperactivity disorder (ADHD) has a
high prevalence but the neurobiological mechanisms
underlying ADHD remain unclear. We characterize resting
EEG-fMRI coupling differences between ADHD and controls
by EEG-fMRI. Based on the literature, we expected
EEG-fMRI alterations in central resting and cognitive
control networks. In 33 adults (17 ADHD), frequency-band
specific EEG power was correlated with fMRI signal
alterations during alternating eyes open and closed
blocks (p < 0.05 corrected). We found bidirectional
group differences in low (theta) to high (alpha)
frequency bands in regions of the described networks. We
conclude that sensory- and cognitive processing is
compromised in adults with ADHD.
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