Meeting Banner
Abstract #3942

Resting-state alterations in EEG-fMRI coupling in adults with attention-deficit/hyperactivity disorder

Lars Michels 1,2 , Steffen Bollmann 2 , Diego Manuel Baur 2 , Anthony Schlpfer 3 , Maya Schneebeli 3 , Carmen Ghisleni 2 , Peter Klaver 2,4 , Daniel Brandeis 3,5 , and Ruth O'Gorman 2

1 Institute of Neuroradiology, University Hospital Zurich, Zurich, Zurich, Switzerland, 2 Center for MR-Research, University Childrens Hospital, Zurich, Zurich, Switzerland, 3 Department of Child and Adolescent Psychiatry University of Zrich, University of Zurich, Zurich, Switzerland, 4 Institute of Psychology, University of Zurich, Zurich, Switzerland, 5 Department of Child & Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Ma, Medical Faculty Mannheim / Heidelberg University, Mannheim, Mannheim, Germany

Attention-deficit/hyperactivity disorder (ADHD) has a high prevalence but the neurobiological mechanisms underlying ADHD remain unclear. We characterize resting EEG-fMRI coupling differences between ADHD and controls by EEG-fMRI. Based on the literature, we expected EEG-fMRI alterations in central resting and cognitive control networks. In 33 adults (17 ADHD), frequency-band specific EEG power was correlated with fMRI signal alterations during alternating eyes open and closed blocks (p < 0.05 corrected). We found bidirectional group differences in low (theta) to high (alpha) frequency bands in regions of the described networks. We conclude that sensory- and cognitive processing is compromised in adults with ADHD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here