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Abstract #3962

Investigation of local brain activity changes in restless legs syndrome using regional homogeneity: a preliminary study

Yong Zhang 1 , Kang-An Li 2 , Yun-Cheng Wu 2 , Qian Jiang 1 , Zhenyu Zhou 3 , and Gui-Xiang Zhang 2

1 GE Healthcare China, Shanghai, Shanghai, China, 2 Shanghai First Peoples Hospital, Shanghai, Shanghai, China, 3 GE Healthcare China, Beijing, Beijing, China

This preliminary study used regional homogeneity (ReHo), a novel resting-state fMRI parameter to investigate local brain activity changes in restless legs syndrome (RLS), a common neurological disorder characterized by an urge to move the legs and paraesthesias deep in the legs. Ten RLS patients and ten age- and gender-matched healthy controls were recruited for comparison. The RLS group showed increased ReHo regions in bilateral middle frontal gyrus, anterior cingulate cortex, caudate nucleus, insula, left putamen and thalamus as compared to normal controls, which might provide interesting insight into the mechanism of the disease.

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