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Abstract #3976

Oxygen-Enhanced Ventilation Mapping of Whole Lungs using 3D UTE at 3T

Crystal E. Harrison 1 , Masaya Takahashi 1 , Robert E. Lenkinski 1 , and Ananth J. Madhuranthakam 1

1 Radiology and Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Chronic obstructive pulmonary disease (COPD) disrupts pulmonary ventilation and perfusion. Oxygen-Enhanced (OE) MRI can probe pulmonary ventilation with inhaled molecular oxygen as an exogenous T 1 contrast agent. One of the primary challenges of lung imaging is the short T 2 * of the lung tissue. Ultrashort echo time (UTE) radial acquisitions minimize this signal loss and SNR at short TE is higher for 3 T than 1.5 T as is the change in T 1 due to inhaled O 2 . The purpose of the current study is to demonstrate the feasibility of performing the OE-UTE ventilation mapping in human subjects at 3 T.

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