Oxygen-Enhanced Ventilation Mapping of Whole Lungs using 3D UTE at 3T

Chronic obstructive pulmonary disease (COPD) disrupts pulmonary ventilation and perfusion. Oxygen-Enhanced (OE) MRI can probe pulmonary ventilation with inhaled molecular oxygen as an exogenous T ₁ contrast agent. One of the primary challenges of lung imaging is the short T ₂ * of the lung tissue. Ultrashort echo time (UTE) radial acquisitions minimize this signal loss and SNR at short TE is higher for 3 T than 1.5 T as is the change in T ₁ due to inhaled O ₂ . The purpose of the current study is to demonstrate the feasibility of performing the OE-UTE ventilation mapping in human subjects at 3 T.

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